Solid lipid nanoparticles of Annona muricata fruit extract: formulation,optimization and in vitro cytotoxicity studies

The present study was aimed to develop Annona muricata fruit extract loaded solid lipid nanoparticles (SLNs) and explore its cytotoxic potential in vitro model of breast cancers. Extract loaded SLNs were successfully prepared by high-pressure homogenization followed by ultrasonication method and optimized using 2³ full factorial design. The extract loaded SLNs were characterized using different parameters such as particle size (PS), % entrapment efficiency (EE), zeta potential (ZP) and % cumulative drug release (CDR). The SLNs formulation was optimized on the basis of software analysis with an overall desirability factor. The PS and %EE of the optimized formulation were found to be 134.8?nm and 83.26%, respectively. The optimized formulation showed a CDR of 79.83% up to 48?h. In vitro cytotoxicity efficacy of extract loaded SLNs was determined using MTT and Apoptosis assay and compared to that of a free extract. The SLNs showed a notable apoptotic effect and better efficacy to kill MCF7 cancer cells as compared to free extract. Thus, extract loaded SLNs could be an alternative dosage form which possibly controls therapeutic action with reducing side effect.     

A Three-Component Mathematical Model of a Single-Axis Accelerometer for Measuring Pitch and Roll Angles

Measurement Techniques - We consider measurements of pitch and roll angles using compensation pendulum accelerometers with closed feedback. A three-component mathematical model of a single-axis...     

Estimating the Electric Mode Effect (Active and Passive) on the Dose of Radiation Resistance of Microcircuits

Russian Microelectronics - Experimental studies on the influence of the electric mode (active and passive) on dose of the radiation resistance of microcircuits of different structural and...     

Solution‐Processable Photonic Inks of Mie‐Resonant Hollow Carbon–Silica Nanospheres

Hollow carbon–silica nanospheres that exhibit angle‐independent structural color with high saturation and minimal absorption are made. Through scattering calculations, it is shown that the structural color arises from Mie resonances that are tuned precisely by varying the thickness of the shells. Since the color does not depend on the spatial arrangement of the particles, the coloration is angle independent and vibrant in powders and liquid suspensions. These properties make hollow carbon–silica nanospheres ideal for applications, and their potential in making flexible, angle‐independent films and 3D printed films is explored.     

Thermal imaging of time-varying longitudinal defects in the internal coating of a tube

We deal with the mathematical model of the incremental degradation of the internal coating (e.g. a polymeric material) of a metallic pipe in which a fluid flows relatively fast. The fluid drags solid impurities so that longitudinal scratches, inaccessible to any direct inspection procedure, are produced on the coating. Time evolution of this kind of defects can be reconstructed from the knowledge of a sequence of temperature maps of the external surface. The time-varying orthogonal section of this damaged interface is determined as a function of time and polar angle through the identification of a suitable effective heat transfer coefficient by means of Thin Plate Approximation.     

New approach to identify the initial condition in degenerate hyperbolic equation

This paper deals with the determination of an initial condition in degenerate hyperbolic equation from final observations. With the aim of reducing the execution time, this inverse problem is solved using an approach based on double regularization: a Tikhonov’s regularization and regularization in equation by viscose-elasticity. So, we obtain a sequence of weak solutions of degenerate linear viscose-elastic problems. Firstly, we prove the existence and uniqueness of each term of this sequence. Secondly, we prove the convergence of this sequence to the weak solution of the initial problem. Also we present some numerical experiments to show the performance of this approach.     

Parameter estimation for a morphochemical reaction-diffusion model of electrochemical pattern formation

The process of electrodeposition can be described in terms of a reaction-diffusion partial differential equation (PDE) system that models the dynamics of the morphology profile and the chemical composition. Here we fit such a model to the different patterns present in a range of electrodeposited and electrochemically modified alloys using PDE constrained optimization. Experiments with simulated data show how the parameter space of the model can be divided into zones corresponding to the different physical patterns by examining the structure of an appropriate cost function. We then use real data to demonstrate how numerical optimization of the cost function can allow the model to fit the rich variety of patterns arising in experiments. The computational technique developed provides a potential tool for tuning experimental parameters to produce desired patterns.     

The Influence of Segregation of Mn on the Recrystallization Behavior of C-Mn Steels

Metallurgical and Materials Transactions B - The influence of Mn segregation that occurs during casting on recrystallization kinetics has been explored for a C-Mn automotive steel. A homogenization...     

The rural–urban equity nexus of Metro Manila’s water system

ABSTRACT

This article examines equity concerns and inherent conflicts related to rural–urban water supply allocation and use, with focus on Metro Manila. Going beyond the much-discussed difficulty farmers experience from an allocation policy prioritizing urban water requirements, it shows that inequity in raw water allocation is linked to, and further exacerbated by, inequities in urban domestic water provision. Moreover, it highlights the need for broader equity reviews, using the concept of the rural–urban water equity nexus to draw attention to key equity considerations across space and scale that otherwise might remain invisible.